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脑膜炎奈瑟氏菌中的W135群在国外已引起多起暴发流行。为提高对W135群流脑的认识,该文整理分析国内已发表病例和石家庄市1例资料。我国2006至2015年3月共报告18例散发病例,病例聚集在东南部和中东部的10省;以农村为主(城乡比1∶8);男性较多(1.6∶1),10~19岁组占50.0%,以学生和民工为主;2~4月占50.0%;8例密切接触者呈现带菌现象。省市级医院24h临床诊断6例;患者临床表现、血和脑脊液标本检测结果典型,W135对抗生素敏感性较好;经青霉素、头孢类抗生素、激素类及对症治疗,12例痊愈或好转出院,6例死亡,病死率33.3%。
The W135 group in Neisseria meningitidis has caused a number of outbreaks in foreign countries. In order to raise awareness of W135 group meningitis, this article analyzed and analyzed the published data of one case in China and one case of Shijiazhuang. A total of 18 cases of sporadic cases were reported in China from March 2006 to March 2015. The cases were clustered in 10 provinces in the southeast and the middle east. Rural areas were predominant (rural-urban ratio was 1: 8); males were more (1.6: 1) The age group accounted for 50.0%, mainly students and migrant workers; 2 ~ April accounted for 50.0%; 8 cases of close contacts showed carriage. Provincial and municipal hospitals in 24h clinical diagnosis of 6 cases; clinical manifestations, blood and cerebrospinal fluid specimens typical test results, W135 sensitivity to antibiotics better; penicillin, cephalosporins antibiotics, hormones and symptomatic treatment, 12 patients cured or improved discharge, 6 died, the case fatality rate was 33.3%.