肿瘤坏死因子(Tumor Necrosis,TNF)由活化的单核/巨噬细胞产生(称为TNF_α),也可由活化的T淋巴细胞及NK细胞产生(称为TNFβ及TNF_α)。TNF最明显的活性特征是可以在体内或体外特异地杀伤肿瘤细胞,对正常组织细胞则无明显的毒性作用。TNF的生物效应是通过TNF受体(TNFR)产生,TNF分为TNF_α及TNFβ。本文着重对TNF_αR近年来的研究进展作一综述。 Tumor necrosis factor (TNF) is produced by activated monocytes / macrophages (called TNFα) and is also produced by activated T lymphocytes and NK cells (termed TNFβ and TNFα). The most obvious active characteristic of TNF is that it can kill tumor cells in vitro or in vivo specifically and has no obvious toxic effect on normal tissue cells. The biological effects of TNF are produced by TNF receptors (TNFRs), which are classified as TNF alpha and TNF beta. This article focuses on the research progress of TNF_αR in recent years.