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目的探讨前列腺癌(PCa)患者尿肌氨酸与血清前列腺特异性抗原(PSA)在早期诊断中的相关性。方法采用肌氨酸氧化酶法对21例PCa患者、17例良性前列腺增生症(BPH)患者和50例健康体检男性进行尿标本的肌氨酸含量检测,并比较各组间尿肌氨酸含量的差异及其与血清PSA水平、PCa病理分级的关系。结果 PCa患者的尿肌氨酸和血清PSA水平均明显高于BPH患者(P<0.05),但两者间无相关关系(r2=0.04,P>0.05)。PCa患者的Gleason评分越高,尿液中肌氨酸含量也越高(P<0.05),而与血清PSA水平无关(P>0.05)。结论随着PCa病理分级的增高,尿肌氨酸含量亦增高,检测尿液中肌氨酸含量有助于PCa的筛检和早期诊断。
Objective To investigate the correlation between urine sarcosine and serum prostate specific antigen (PSA) in early diagnosis of prostate cancer (PCa). Methods The sarcosine of 21 PCa patients, 17 benign prostatic hyperplasia (BPH) patients and 50 healthy male volunteers were detected by the method of sarcosine oxidase. Urinary sarcosine And its relationship with serum PSA level and PCa pathological grade. Results Urinary sarcosine and serum PSA levels in PCa patients were significantly higher than those in BPH patients (P <0.05), but no correlation was found between them (r2 = 0.04, P> 0.05). The higher the Gleason score in PCa patients, the higher the creatine content in urine (P <0.05), but not the serum PSA level (P> 0.05). Conclusions As the pathological grade of PCa increases, the content of urine creatine increases. The determination of sarcosine in urine can help the screening and early diagnosis of PCa.