Traumatic brain injury (TBI) is a major cause of mortality and morbidity in the pediatricpopulation. With advances in medical care, the mortality rate of pediatric TBI hasdeclined. However, more children and adolescents are living with TBI-related cognitiveand emotional impairments, which negatively affects the quality of their life. Adulthippocampal neurogenesis plays an important role in cognition and mood regulation.Alterations in adult hippocampal neurogenesis are associated with a variety of neurological and neurodegenerative diseases, including TBI. Promoting endogenous hippocampalneurogenesis after TBI merits significant attention. However, TBI affects the functionof neural stem/progenitor cells in the dentate gyrus of hippocampus, which results inaberrant migration and impaired dendrite development of adult-born neurons. Therefore, a better understanding of adult hippocampal neurogenesis after TBI can facilitate a more successful neuro-restoration of damage in immature brains. Secondary injuries, suchas neuroinflammation and oxidative stress, exert a significant impact on hippocampalneurogenesis. Currently, a variety of therapeutic approaches have been proposedfor ameliorating secondary TBI injuries. In this review, we discuss the uniqueness ofpediatric TBI, adult hippocampal neurogenesis after pediatric TBI, and current efforts that promote neuroprotection to the developing brains, which can be leveraged to facilitate neuroregeneration.