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目的:探讨C反应蛋白(CRP)自身抗体与急性冠脉综合征(ACS)患者冠脉病变严重程度、斑块不稳定的相关性。方法:应用间接酶联免疫吸附法检测120例ACS,61例稳定型心绞痛(SAP)和120例对照者血清CRP自身抗体吸光度(A)值,并以对照组的95%可信区间A值作为判断CRP自身抗体阳性或阴性的界点。结果:ACS征组血浆CRP自身抗体A值水平(1.75±1.09)显著高于SAP(1.27±0.61)和对照组(0.88±0.43),P<0.001,并与冠状动脉病变积分无相关性(P>0.05)。ACS组CRP自身抗体阳性比例(44.17%)显著高于SAP组(8.84%),P<0.001。结论:CRP自身抗体不是反映ACS患者冠状动脉病变严重程度的指标,CRP自身抗体水平可能是随着斑块不稳定而变化的,与ACS患者斑块不稳定相关,但CRP自身抗体在ACS中的作用机制尚不明了。
Objective: To investigate the correlation between C-reactive protein (CRP) autoantibodies and coronary artery disease severity and plaque instability in patients with acute coronary syndrome (ACS). Methods: Serum CRP autoantibody Absorbance (A) of 120 patients with ACS, 61 patients with stable angina pectoris (SAP) and 120 controls were detected by indirect enzyme - linked immunosorbent assay. The 95% confidence interval A value of the control group was taken as Judgment CRP autoantibodies positive or negative point of the junction. Results: The level of plasma CRP autoantibodies in patients with ACS was (1.75 ± 1.09) significantly higher than those in SAP (1.27 ± 0.61) and controls (0.88 ± 0.43), P <0.001, and had no correlation with coronary artery disease scores > 0.05). The positive rate of CRP autoantibody in ACS group (44.17%) was significantly higher than that in SAP group (8.84%), P <0.001. CONCLUSIONS: CRP autoantibodies are not indicators of the severity of coronary lesions in patients with ACS. The levels of CRP autoantibodies may vary with plaque instability and are associated with plaque instability in patients with ACS, but CRP autoantibodies in ACS The mechanism of action is not clear.