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本文研究了小鼠皮两种去毛方法、接收液的搅拌速度和温度、用大鼠皮或小鼠皮进行实验的影响。发现用脱毛法处理的鼠皮酮基布洛芬的透过速率略低于剃毛法,当接收液的搅拌加快和温度升高透过速率均提高。温度的影响显著。从31℃升至37℃酮基布洛芬的渗透提高约40%、酮基布洛芬透过大鼠皮比小鼠皮约慢30%。
In this paper, two methods of dehairing mouse skin, the speed and temperature of the receiving solution, and the effects of experiments with rat skin or mouse skin were studied. It was found that the rate of penetration of rat skin-based ibuprofen treated with the hair removal method was slightly lower than that of the shaving method, and the rate of permeation increased as the receiving liquid was stirred rapidly and the temperature was raised. The impact of temperature is significant. The penetration of ketoprofen increased from 31 ° C to 37 ° C by about 40% and that of ketoprofen 30% slower than that of rat skin dermis.