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化学修饰是改善药用蛋白质的免疫原性、半衰期等生物学特性的有效方式,已经成为生物化学和分子生物学领域的研究热点之一。本文主要介绍常用化学修饰剂的种类及其性质,评述化学修饰的方式和原理,列举化学修饰蛋白质在生物医药领域的应用。
Chemical modification is an effective way to improve the biological properties of immunogenicity, half-life and other biological properties of medicinal proteins. It has become one of the hot topics in the field of biochemistry and molecular biology. This article mainly introduces the types and properties of commonly used chemical modifiers, reviews the ways and principles of chemical modification, and lists the application of chemically modified proteins in the field of biomedicine.