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遗传学、脂蛋白及动脉粥样硬化人口统计资料表明,膳食、体重、运动及烟癖等因素对心血管病易感性均至关重要。但综合流行病学及临床所见,上列因素并未对人口总体中所有人员的心血管病易感性作出解释。有些人能带病延年至八、九十岁(所谓的温斯顿·丘吉尔症候群,“WinstonChurchill Syndrome”),另一些人则虽供以合理膳食、既无超重、也颇活跃、更无烟癖者,却在20岁、30岁或40岁左右就罹患心肌梗塞。显然,此两组人群间必定存在根本差别。有人解释谓,前组人群具有内在的或遗传性的防止心脏病发作的因素,而后组人群则有早发心脏病的遗传因素。流行病学研究表明,血内运载胆固醇的复合物,即脂蛋白的水平,
Genetics, lipoprotein and atherosclerosis demographics suggest that factors such as diet, weight, exercise and smoking prevalence are central to cardiovascular disease susceptibility. However, the comprehensive epidemiological and clinical findings, the above factors did not explain the cardiovascular disease susceptibility of all population population. Some people can be sick for up to eighty or ninety years of age (the so-called Winston Churchill Syndrome) while others are not overweight, active, or smoke-free Invaders, however, suffer from myocardial infarction at the age of 20, 30, or 40 years. Obviously, there must be a fundamental difference between the two groups of people. Someone explained that the former group of people have an intrinsic or genetic factor to prevent a heart attack, while the latter group of people have a genetic predisposition to heart disease. Epidemiological studies have shown that cholesterol-carrying complexes in the blood, the level of lipoprotein,