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灌肠治疗直肠炎或左侧溃疡性结肠炎的优点在于能到达结肠脾曲。布地缩松对糖皮质激素受体有高度亲和力,因而有高度局部表面抗炎作用,并且由于肝脏的首过代谢作用大而对全身作用小。此研究比较三种剂量布地缩松及安慰剂灌肠治疗活动性远段溃疡性结肠炎,以评价疗效及安全性。
The advantage of enema in the treatment of proctitis or ulcerative colitis on the left is to reach colon splenic flexure. Budesonide has a high affinity for glucocorticoid receptors and thus a highly localized topical anti-inflammatory effect and is less systemic to the body due to the large first-pass metabolism of the liver. This study compared three doses of budesonide and placebo enema for the treatment of distal ulcerative colitis in order to evaluate the efficacy and safety.