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目的:表面活性剂在固体脂质纳米粒的制备过程中扮演着重要角色,为规避药物对体系的影响,本文选用4种表面活性剂制备了空白而具有良好物理稳定性的固体脂质纳米粒混悬液。方法:用激光散射粒度仪和Zeta电位分析仪(LD)检测平均粒径、颗粒分布范围和Zeta电位,另外还进行了DSC热分析和颗粒形态的TEM观察。结果:离子型表面活性剂脱氧胆酸钠可以提高纳米粒的Zeta电位从而提高系统物理稳定性,但乳化率低;非离子乳化剂Pluronic F-68可以起到空间稳定的作用从而避免胶体系统中颗粒的聚结。结论:4种表面活性剂的复配[两种非离子乳化剂(Pluronic F-68和Tween80),离子型表面活性剂(脱氧胆酸钠)以及卵磷脂]可以制备稳定6个月而不分层的纳米混悬液。
OBJECTIVE: Surfactants play an important role in the preparation of solid lipid nanoparticles. In order to avoid the influence of drugs on the system, four kinds of surfactants were used to prepare solid lipid nanoparticles with good physical stability Suspension. Methods: The average particle size, particle size distribution and Zeta potential were measured by laser light scattering particle size analyzer and Zeta potential analyzer (LD). DSC thermal analysis and TEM observation of particle morphology were also performed. Results: The ionic surfactant sodium deoxycholate can increase the Zeta potential of the nanoparticles to improve the physical stability of the system, but the emulsification rate is low. The non-ionic emulsifier Pluronic F-68 can play a steric stabilizing role in the colloidal system Coalescence of particles. CONCLUSIONS: Four surfactant combinations [two nonionic emulsifiers (Pluronic F-68 and Tween 80), ionic surfactants (sodium deoxycholate) and lecithin] can be prepared for 6 months without distinction Layer of nanosuspension.