AIM: To identify gaps in the existing knowledge on single,dual and triple infections of human immunodeficiency virus(HIV),hepatitis B virus(HBV) and hepatitis C virus(HCV) in the Middle East and North Africa(MENA) region among men who have sex with men(MSMs),female sex workers(FSWs),injecting drug users(IDUs) and prisoners.METHODS: We performed an extensive literature search on articles published on the topic in the 25 countries of the MENA region.Pub Med database was used as the main search engine.Case reports,case series,qualitative studies,editorials,commentaries,authors’ replies and animal studies were excluded.Original articles and reviews dealing with the prevalence of HIV,HBV and HCV and their co-infection were included.Data on population type,sample size,age and markers of infections were extracted from the relevant studies.RESULTS: HIV,HBV and HCV are blood-borne viruses with similar modes of transmission.The categories of people at high risk of acquiring HIV-1,HBV and HCV commonly include: MSMs,FSW and IDUs.It is well established that HIV-positive individuals co-infected with HBV or HCV suffer from liver pathology associated with morbidity and mortality.Moreover,HIV-infected individuals do not respond well to treatment for HBV or HCV and hence are at increased risk of hepatic toxicity.Consequently,co-infection of HIV-positive individuals with HBV and/or HCV is a global health problem ofsignificant magnitude.Our review reveals the paucity of epidemiological data for key populations in many countries of the region.Limited number of studies exists in the MENA region on the status of HIV,HBV and HCV and their co-infections among prisoners,MSMs and FSWs.Evidence support the continued increase of the HIV epidemic among MSMs.In addition to the lack of studies on MSMs and FSWs in the MENA region,our review highlights the lack of data on the practices,characteristics,or the status of HIV infection and viral hepatitis among male sex workers selling or exchanging sex for money.CONCLUSION: The MENA countries are in urgent need of advanced research and strengthening of the data collection systems and reporting practices of these infections among key populations. AIM: To identify gaps in the existing knowledge on single, dual and triple infections of human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) in the Middle East and North Africa (MENA) region among men who have sex with men (MSMs), female sex workers (FSWs), injecting drug users (IDUs) and prisoners. METHODS: We performed an extensive literature search on articles published in the 25 countries of the MENA region. Pub Med database was used as the main search engine. Case reports, case series, qualitative studies, editorials, commentaries, authors’ replies and animal studies were excluded. OEM articles and reviews dealing with the prevalence of HIV, HBV and HCV and their co-infection were included. Data on population type, sample size, age and markers of infections were extracted from the relevant studies .RESULTS: HIV, HBV and HCV are blood-borne viruses with similar modes of transmission. HIV-1, HBV and HCV com monly include: MSMs, FSW and IDUs.It is well established that HIV-positive individuals co-infected with HBV or HCV suffer from liver pathology associated with morbidity and mortality. Moreover, HIV-infected individuals do not respond well to treatment for HBV or HCV and therefore are at increased risk of hepatic toxicity. Conclusion, co-infection of HIV-positive individuals with HBV and / or HCV is a global health problem of scientific magnitude. Our review reveals the paucity of epidemiological data for key populations in many countries of the region. Limited number of studies exists in the MENA region on the status of HIV, HBV and HCV and their co-infections among prisoners, MSMs and FSWs.Evidence support the continued increase of the HIV epidemic among MSMs.In addition to the lack of studies on MSMs and FSWs in the MENA region, our review highlights the lack of data on the practices, characteristics, or the status of HIV infection and viral hepatitis among male sex workers selling or exchanging sexfor money.CONCLUSION: The MENA countries are in urgent need of advanced research and strengthening of the data collection systems and reporting practices of these infections among key populations.