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采用免疫组化方法测定 5 8例急性髓系细胞白血病患者抗凋亡基因bcl 2蛋白表达水平 ,分析bcl 2基因与临床预后关系。结果表明 ,高表达bcl 2患者 ,化疗反应差 ,预后不良。提示bcl 2表达水平可作为判断急性髓系细胞白血病预后的重要指标之一。
Immunohistochemistry was used to detect the expression of anti-apoptotic gene bcl-2 protein in 58 acute myeloid leukemia patients. The relationship between bcl-2 gene and clinical prognosis was analyzed. The results showed that patients with high expression of bcl 2 had poor response to chemotherapy and poor prognosis. Tip bcl 2 expression levels can be used as an important indicator to determine the prognosis of acute myeloid leukemia.