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目的评价三维适形放疗结合同步化疗方案治疗不能手术的Ⅲ期非小细胞肺癌(NSCLC)疗效。方法将54例均经纤维支气管镜、穿刺活检病理或细胞学证实不能手术的NSCLC患者(Ⅲa期23例,Ⅲb期31例),按随机表分配法分成两组:放化组和单放组各27例。比较2组疗效及毒副反应。结果2组总有效率相比,差异有统计学意义(P<0.05)。放化疗组较单纯放疗组局控率高,1～3年生存率放化组比单放组好,差异有统计学意义(P<0.05)。2组毒副反应比较,差异均无统计学意义,P>0.05。结论三维适形放疗同步化疗治疗Ⅲ期NSCLC能够提高肿瘤的照射剂量,降低周围正常组织的损伤,使肿瘤局部控制率提高,有较好的近期疗效,患者能耐受其毒副作用。
Objective To evaluate the efficacy of three-dimensional conformal radiotherapy combined with concurrent chemotherapy in the treatment of inoperable stage Ⅲ non-small cell lung cancer (NSCLC). Methods Totally 54 NSCLC patients (23 cases in stage Ⅲa and 31 cases in stage Ⅲb) who were confirmed by fiberoptic bronchoscopy, biopsy pathology or cytology were divided into two groups according to random table allocation: radiotherapy group and radiotherapy group 27 cases in each. Compare the two groups efficacy and toxicity. Results The total effective rate in the two groups, the difference was statistically significant (P <0.05). Radiotherapy and chemotherapy group than radiotherapy alone control rate, 1 to 3 years survival rate radiotherapy group than radiotherapy group, the difference was statistically significant (P <0.05). There were no significant differences in the side effects between the two groups (P> 0.05). Conclusions The three-dimensional conformal radiotherapy combined with concurrent chemotherapy for stage III NSCLC can improve tumor radiation dose, reduce the damage of surrounding normal tissue, improve the local control rate of tumor, have better short-term curative effect, and patients can tolerate its side effects.