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目的探讨降钙素原(PCT)在判断类风湿关节炎(RA)合并感染病原菌中的临床价值,以辅助临床早期诊治。方法采用回顾性研究,选取2011年6月-2013年12月住院的RA合并感染患者116例。研究各种病原菌与PCT浓度的相关性,计算RA合并感染革兰阴性菌、革兰阳性菌、真菌及支原体、病毒患者的PCT浓度。结果 RA合并感染病原体的PCT浓度(ng/ml):革兰阴性菌组(3.65±0.99)>革兰阳性菌组(2.29±0.85)>真菌及支原体组(1.22±0.78)>病毒组(0.41±0.16),各组间差异有统计学意义(P<0.05,P<0.01)。结论 RA合并感染病原菌与降钙素原水平有一定的相关性,定量测定PCT可辅助诊断RA合并感染病原菌种。
Objective To investigate the clinical value of procalcitonin (PCT) in judging rheumatoid arthritis (RA) co-infected pathogens to aid early clinical diagnosis and treatment. Methods A retrospective study was conducted to select 116 patients with RA-co-infected patients admitted to hospital from June 2011 to December 2013. The correlation between various pathogenic bacteria and PCT concentration was studied, and the PCT concentration of RA patients with Gram-negative bacteria, Gram-positive bacteria, fungi, mycoplasmas and viruses was calculated. Results The PCT concentration (ng / ml) of RA-infected pathogens: Gram-negative bacteria group (3.65 ± 0.99)> Gram-positive bacteria group (2.29 ± 0.85)> Fungal and mycoplasma group (1.22 ± 0.78) ± 0.16). The differences among the groups were statistically significant (P <0.05, P <0.01). Conclusion The pathogen of RA combined infection has some correlation with the level of procalcitonin. Quantitative determination of PCT can be used to diagnose the pathogen of RA combined infection.