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1967年,Sanstead等在埃及和伊朗发现,具有侏儒症、生殖器发育障碍、缺铁性贫血和食土症等特征的疾病,属于锌缺乏症。锌剂治疗可促进生长发育和第二性征的出现。1973年,Barnes等对用合成食品喂养的2岁患肠病性肢皮炎(acrodermatitis enteropathica,AE)小儿,分析其食品中锌含量不足,血浆锌低于5.36μmol/L(35μg/dl),服用硫酸锌后,血浆锌恢复到正常,其症状完全消失。1975年认识到AE是皮肤科领域的遗传性锌缺乏症。在外科,Kay等在高热量输液患者的恢复期中,注意到
In 1967, Sanstead et al. Found in Egypt and Iran that the diseases characterized by dwarfism, developmental genitalia, iron deficiency anemia and soil-borne diseases are zinc deficiency. Zinc treatment can promote the growth and development and secondary sexual characteristics appear. In 1973, Barnes et al. Analyzed 2-year-old children with acrodermatitis enteropathica (AE) who were fed on synthetic foods, who were deficient in zinc content in their food, plasma zinc was below 5.36 μmol / L (35 μg / dl) Zinc sulfate, plasma zinc returned to normal, the symptoms disappeared completely. Recognized in 1975 that AE is an inherited zinc deficiency in the field of dermatology. In surgery, Kay et al. Noted during the recovery period of patients with hyperthermic fluids