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建立了定量分析饮用水中双酚A(BPA)的固相萃取-液相色谱-质谱联用法。SupelcleanTM ENVI-18TM SPE固相萃取柱富集水样中BPA,上样流速1~2 m L/min,9 m L甲醇洗脱,氮吹定容后,采用液相色谱-质谱联用仪检测,ZORBAX Extend-C18色谱柱为4.6 mm×150 mm,5μm,负离子模式,干燥气流速11 L/min、干燥气温度350℃、雾化气压力35 psi,选择离子监测m/z 227。用超纯水配制浓度范围122.9~1 190.7 ng/L的水样,经样品前处理后上机检测,建立一级质谱峰面积-浓度标准曲线,线性回归方程为y=69.4x+2 186.1,相关系数为0.992 9。方法的检出限为7.0 ng/L,回收率为77.6%~104.0%,相对标准偏差(n=6)≤14%。该方法简单、灵敏、准确,可应用于饮用水中痕量BPA的检测。
A quantitative solid-phase extraction-liquid chromatography-mass spectrometry method for the determination of bisphenol A (BPA) in drinking water was established. Superexample ENVI-18 SPE was used to enrich BPA in water sample, the flow rate was 1 ~ 2 m L / min and methanol was eluted with 9 mL of methanol. After the nitrogen was allowed to blow, the sample was analyzed by liquid chromatography-mass spectrometry The ZORBAX Extend-C18 column has a 4.6 mm × 150 mm, 5 μm, negative ion mode with a dry gas flow rate of 11 L / min, a dry gas temperature of 350 ° C and a nebulizer pressure of 35 psi. The water sample with the concentration range of 122.9-1 190.7 ng / L was prepared with ultrapure water. The sample was pretreated and then tested on the machine to establish a standard peak-area concentration-concentration curve. The linear regression equation was y = 69.4x +2 186.1, The correlation coefficient is 0.992 9. The detection limit of the method was 7.0 ng / L, the recovery was 77.6% ~ 104.0%, and the relative standard deviation (n = 6) ≤14%. The method is simple, sensitive and accurate and can be applied to the determination of trace BPA in drinking water.