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对15例血液病患者进行了骨髓或外周血培养细胞的染色体观察。15例中12例临床确诊为慢性粒细胞白血病,2例诊断为急性粒细胞白血病,1例为继发性红细胞增生症。在12例慢性粒细胞白血病中,11例Ph~1染色体为阳性(阳性率平均为72.3％),1例为Ph~1阴性;2例急性粒细胞白血病患者的骨髓中期分裂细胞具Ph~1染色体者分别占1/4及1/5,其中1例还发现微小体;1例继发性红细胞增生症患者,70％的骨髓中期分裂细胞为Ph~1染色体阳性,并发现染色体碎裂细胞。
Chromosomal observations of cultured bone marrow or peripheral blood cells were performed on 15 patients with hematologic disorders. Of the 15 cases, 12 were clinically diagnosed as chronic myeloid leukemia, 2 were diagnosed as acute myeloid leukemia and 1 was secondary erythrocytosis. Of the 12 chronic myelogenous leukemias, 11 were Ph ~ 1 positive (positive rate was 72.3%) and 1 was negative for Ph ~ 1. The metaphase cells of two patients with acute myeloid leukemia had Ph ~ 1 Chromosomes accounted for 1/4 and 1/5, of which 1 also found that the body; 1 case of patients with secondary erythrocytosis, 70% of the bone marrow metaphase cells were Ph ~ 1 chromosome positive and found that chromosome fragments .