论文部分内容阅读
目的研究血浆肾素(PRA)、血管紧张素Ⅱ(AngⅡ)异常的防治对急性脑梗死(ACI)患者预后的影响。方法 89例急性脑梗死2周后血浆肾素、血管紧张素Ⅱ水平异常患者随机分成两组,厄贝沙坦组(45例)和常规对照组(44例),连续治疗1个月。在治疗前和治疗1个月后用美国国立卫生研究院卒中评分(NationalInsitutes of Health Stroke Scale,NIHSS)进行神经功能评分。结果厄贝沙坦组神经功能缺损评分低于常规对照组,差异有统计学意义(P﹤0.05)。结论急性脑梗死恢复期伴发血浆肾素、血管紧张素Ⅱ异常的患者预后不良,应进行积极防治。
Objective To study the effects of prevention and treatment of plasma renin (PRA) and angiotensin Ⅱ (Ang Ⅱ) on the prognosis of patients with acute cerebral infarction (ACI). Methods Eighty-nine patients with abnormal plasma renin and angiotensin Ⅱ levels after 2 weeks of acute cerebral infarction were randomly divided into two groups: irbesartan group (n = 45) and conventional control group (n = 44) for 1 month. Neurological scores were assessed before treatment and one month after treatment with the National Institutes of Health Stroke Scale (NIHSS). Results The score of neurological deficit in irbesartan group was lower than that of the control group (P <0.05). Conclusions Patients with abnormal plasma renin and angiotensin Ⅱ during the recovery of acute cerebral infarction have a poor prognosis and should be actively controlled.