6例经病毒唑和安慰剂治疗的早期流行性出血热(EHF)患者治疗前后血小板超微结构研究结果表明:疾病早期即有大量血小板变性、空泡化、膜裂解及不可逆性的血小板聚集体出现,α颗粒明显减少;经病毒唑治疗后或疾病恢复过程时,血小板结构则趋向正常,α颗粒明显增加,但治疗组优于安慰剂组。研究结果认为患者血小板数量减少及功能障碍与其结构破坏密切相关,病毒唑治疗EHF 有效。 The results of platelet ultrastructural studies before and after treatment in 6 patients with early epidemic hemorrhagic fever (EHF) treated with ribavirin and placebo showed that there were a lot of platelet degeneration, vacuolization, membrane lysis, and irreversible platelet aggregation in the early stage of disease. The appearance of alpha particles was significantly reduced; after treatment with ribavirin or during disease recovery, the platelet structure tended to be normal and the alpha particles increased significantly, but the treatment group was superior to the placebo group. The results of the study suggest that the decrease in platelet count and dysfunction in patients are closely related to structural destruction. Ribavirin is effective in treating EHF.