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目的研究高血压视网膜病变(HRP)患者血浆内皮素-1的表达及其与视网膜病变的相关性。方法选择HRP患者120例,其中Ⅰ级和Ⅱ级HRP患者各60例,60例健康体检人员作为对照。抽取外周血,应用酶联免疫吸附测定法检测血浆内皮素-1(ET-1)水平,并分析HRP严重程度与ET-1水平的关系。结果对照组、Ⅰ级、Ⅱ级HRP患者血浆ET-1含量依次增加,分别为(46.4±10.8)、(80.9±13.2)、(98.6±11.7)pg/m L,总体差异有统计学意义(F=296.54,P=0.029)。结论 ET-1水平异常可能与高血压视网膜病变的发生有一定关系。
Objective To investigate the expression of plasma endothelin-1 and its relationship with retinopathy in patients with hypertensive retinopathy (HRP). Methods 120 cases of HRP patients were selected, of which 60 cases were grade Ⅰ and Ⅱ HRP and 60 cases were used as control. Peripheral blood was collected. The level of plasma endothelin-1 (ET-1) was measured by enzyme linked immunosorbent assay. The relationship between the severity of HRP and the level of ET-1 was also analyzed. Results The levels of plasma ET-1 in the control group, grade Ⅰ and grade Ⅱ HRP patients were respectively (46.4 ± 10.8) and (80.9 ± 13.2) and (98.6 ± 11.7) pg / m L, respectively. The overall difference was statistically significant F = 296.54, P = 0.029). Conclusion The abnormal ET-1 level may be related to the occurrence of hypertensive retinopathy.