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随访观察(平均26个月)72例 HBs 抗原持续阳性小儿(男33名,女39名),观察对象在随访期内完全不曾接受药物治疗。结果表明:(1)HBe 抗原阳性率随小儿年龄之增长而减低,e 抗体阳性率则与龄俱增。HBe 抗原抗体阳性变动情况与性别无甚关联。(2)随访始末期间的 HBe 抗原抗体变动形式:初次检查后,直至最后一次随访时持续保持 HBe 抗抗阳性者50例(69.4%),为最多;发生血清学转变而出现 e 抗体者6例(8.3%);e 抗体持续阳性者11例(15.3%)。另有3例 e 抗原抗体始终均呈阴性。2例 e 抗原阳性者于随访期中自然消失。(3)分组特点:e 抗原持续阳性组,血清学转变组和 e 抗体持续阳性组三组观察例无性别的差异;e 抗体持续阳性组较抗原阳性组多见于年长儿童;血清学转变
Follow-up observation (average 26 months) 72 cases of HBs antigen persistently positive children (33 males and 39 females), the observation group in the follow-up period did not receive medication. The results showed that: (1) The positive rate of HBe antigen decreased with the increase of children’s age, and the positive rate of e antibody increased with age. HBe antigen antibody positive changes have nothing to do with gender. (2) The change of HBe antigen antibody during the follow-up period: 50 cases (69.4%) remained HBeAg positive after the initial examination until the last follow-up, and 6 cases had e antibody after seroconversion (8.3%); e antibody positive in 11 cases (15.3%). Another 3 cases of e antigen antibody always negative. Two patients with positive e antigen disappeared spontaneously during the follow-up period. (3) The characteristics of grouping: e antigen persistent positive group, seroconversion group and e antibody persistently positive group three cases observed no gender differences; e antibody persistent positive group more than antigen positive group more common in older children; serological changes