The transesterification of palm oil and methanol catalyzed by Br?nsted acidic ionic liquids was investigated. Four eco-friendly Br?nsted acidic ionic liquids were prepared and their structures were characterized by NMR, FT-IR and TG–DTG. The results demonstrated that [CyN_(1,1)PrSO_3H][p-TSA] was more efficient than the other ionic liquids and chosen as catalyst for further research. The influences of various reaction parameters on the conversion of palm oil to biodiesel were performed, and the orthogonal test was investigated to seek the optimum reaction conditions, which were illustrated as follows: methanol to oil mole ratio of 24:1, catalyst dosage of 3.0 wt% of oil, reaction temperature of 120 °C, reaction time of 150 min, and the biodiesel yield achieved 98.4%. In addition, kinetic study was established for the conversion process, with activation energy and preexponential factor of 122.93 k J·mol~(-1) and 1.83 × 10~(15), respectively. Meanwhile, seven-time recycling runs of ionic liquid were completed with ignorable loss of its catalyst activity. The refined biodiesel met the biodiesel standard EN 14214. The transesterification of palm oil and methanol catalyzed by Brönsted acidic ionic liquids was investigated. Four eco-friendly Brønssted acidic ionic liquids were prepared and their properties were classified by NMR, FT-IR and TG-DTG. The results act that The influences of various reaction parameters on the conversion of palm oil to biodiesel were performed, and the orthogonal [CyN_ (1,1) PrSO_3H] [p-TSA] was more efficient than the other ionic liquids and chosen as catalyst for further research. test was investigated to seek the optimum reaction conditions, which were illustrated as follows: methanol to oil mole ratio of 24: 1, catalyst dosage of 3.0 wt% of oil, reaction temperature of 120 ° C, reaction time of 150 min, and the biodiesel yield achieved 98.4%. In addition, kinetic study was established for the conversion process, with activation energy and preexponential factor of 122.93 kJ · mol -1 and 1.83 × 10 ~ (15), respectively. Meanwhile, seven- time recycling runs of ionic liquid were completed with ignorable loss of its catalyst activity. The refined biodiesel met the biodiesel standard EN 14214.