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目的 :探讨干扰素α 2b早期治疗肾综合征出血热 (HFRS)的疗效。方法 :采用随机双盲对照研究的方法将患有早期肾综合征出血热病人 6 4例分 2组 ,干扰素组 33例 (男性 2 8例 ,女性 5例 ;年龄2 7±s 6a)在基础治疗上加用干扰素α 2b 10 0万U ,im ,qd× 5d。对照组 31例 (男性 2 7例 ,女性 4例 ;年龄 2 9a± 2a)仅用基础治疗 ,包括抗血浆外渗 ,止血 ,纠正水、电解质和酸碱平衡紊乱 ,抗休克 ,防治肾功能哀竭等。结果 :干扰素组双越期 (越低血压和少尿期 )、三红征消失平均日数、尿蛋白消失及尿素氮恢复正常平均日数均明显少于对照组(P <0 .0 5)。结论 :干扰素α 2b早期治疗肾综合征出血热是合理、有效的。
Objective: To investigate the efficacy of interferon α 2b in early treatment of hemorrhagic fever with renal syndrome (HFRS). Methods: A randomized, double-blind, controlled study was conducted to divide 62 patients with early-stage renal syndrome hemorrhagic fever into 2 groups and 33 patients with interferon (28 males and 5 females; mean age 2 7 ± s 6 a) On the basis of treatment with interferon α 2b 10 million U, im, qd × 5d. The control group of 31 patients (27 males and 4 females; age 29a ± 2a) only with basic treatment, including anti-extravasation of plasma, stop bleeding, correct water, electrolyte and acid-base balance disorders, anti-shock, prevention and treatment of renal function Exhausted. Results: The mean number of disappeared mean days, disappearance of urine protein and normal urea nitrogen return in the interferon group were significantly lower than those in the control group (P <0.05). Conclusions: Early treatment of hemorrhagic fever with renal syndrome by interferon alfa 2b is reasonable and effective.