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目的探讨低剂量克拉霉素四联疗法治疗小儿消化性溃疡的临床效果。方法将210例消化性溃疡患儿随机分为观察组和对照组各105例。观察组应用低剂量克拉霉素四联疗法;对照组采用高剂量克拉霉素拉霉素四联疗法。比较2组患儿的溃疡愈合情况、幽门螺杆菌(Hp)根除率、治疗中腹痛消失时间及药物不良反应。结果观察组溃疡愈合率、Hp清除率高于对照组,腹痛消失时间短于对照组,药物不良反应率低于对照组(P<0.05)。结论低剂量克拉霉素四联疗法治疗小儿消化性溃疡能有效提高溃疡愈合率及Hp清除率,临床疗效显著。
Objective To investigate the clinical effect of low dose clarithromycin quadruple therapy on children with peptic ulcer. Methods A total of 210 children with peptic ulcer were randomly divided into observation group (105 cases) and control group (105 cases). The observation group was treated with low-dose clarithromycin quadruple therapy and the control group with high-dose clarithromycin-coumarin quadruple therapy. The ulcer healing, Helicobacter pylori (Hp) eradication rate, disappearance of mid-abdominal pain and adverse drug reactions were compared between the two groups. Results The ulcer healing rate and Hp clearance rate in the observation group were higher than those in the control group. The disappearance time of abdominal pain was shorter than that of the control group, and the rate of adverse drug reactions was lower than that of the control group (P <0.05). Conclusion Low-dose clarithromycin quadruple therapy for children with peptic ulcer can effectively improve the ulcer healing rate and Hp clearance rate, the clinical curative effect is remarkable.