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婴儿猝死综合征(SIDS)多发于低出生体重婴儿,这提示本病可能与营养缺乏有关。SIDS的发病高峰期在出生后最初3个月,此期婴儿血红蛋白浓度最低,因而怀疑铁可能在SIDS发病中起某种作用。作者对17例SIDS的死婴进行了尸检研究,并测定了肝组织的含铁量。通常婴儿肝组织铁水平随月龄增长而逐渐减低。在出生头两个月中,每克湿肝平均含铁由400mg降至150mg。但本组年龄为3周龄～9月龄的SIDS死婴肝组织铁水平最低为213mg/g,高于预期值2～3倍,其中1例死亡时6周龄、体重4150g的男婴,肝组织铁水平高达1240mg/g。
Sudden Infant Death Syndrome (SIDS) occur frequently in low birth weight infants, suggesting that the disease may be related to nutritional deficiencies. SIDS onset peak in the first 3 months after birth, during which the lowest hemoglobin concentration in infants and therefore suspected iron may play a role in the pathogenesis of SIDS. The authors conducted an autopsy study of 17 infants with SIDS and determined the amount of iron in the liver tissue. Normally, infant liver tissue iron levels gradually decrease with age. In the first two months of life, the average iron content per gram of wet liver is reduced from 400 mg to 150 mg. However, the minimum iron level in the liver tissue of SIDS infants aged 3 weeks to 9 months was 213 mg / g, which was 2 to 3 times higher than the expected value. Among them, 1 case had a 6-week-old baby weighing 4150 g, Liver tissue iron levels up to 1240mg / g.