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乙型肝炎病毒(HBV)感染与肝细胞癌(HCC)关系密切,早在本世纪七十年代已受到重视。1974年英国学者 Zuckerman曾注意到这一点,并提出要确立 HBV 与HCC 的因果关系,需解决以下几点:即证明 HBV 感染应先于 HCC 的发生;肝癌细胞含有特异性 HBV 颗粒或抗原;肝癌细胞能产生 HBV 抗原,HBV 可使培养细胞发生转化或在实验动物诱发肝肿瘤;此外,当肝炎疫苗制备成功后,对 HBV 免疫将会降低HCC 的发病率。近年来的研究结果已大部分解决了上述几点。
Hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC) are closely related, as early as the seventies of this century has been given attention. In 1974, British scholar Zuckerman noticed this and proposed to establish the causal relationship between HBV and HCC. The following points need to be solved: to prove that HBV infection should precede HCC; liver cancer cells contain specific HBV particles or antigens; and liver cancer Cells can produce HBV antigens. HBV can transform cultured cells or induce liver tumors in experimental animals. In addition, immunization with HBV will reduce the incidence of HCC when the hepatitis vaccine is prepared successfully. In recent years, most of the research results have solved the above points.