论文部分内容阅读
目的:测定吴茱萸碱分散片及吴茱萸碱经不同方法处理后的溶出度。方法:依据《中华人民共和国药典》2010年版溶出度测定法第二法(浆法),以1%SDS 900 mL为溶出介质,转速100 r.min-1;制备吴茱萸碱-泊洛沙姆188固体分散体、吴茱萸碱超微粉及吴茱萸碱超微粉-泊洛沙姆188固体分散体,HPLC测定溶出度。结果:吴茱萸碱分散片45 min溶出度>60%;吴茱萸碱超微粉-泊洛沙姆188固体分散体体外溶出度较好。结论:建立的吴茱萸碱分散片溶出度测定方法简便、快速,可作为吴茱萸碱分散片的溶出度检测方法;吴茱萸碱几乎不溶于水,超微粉碎联合固体分散体技术能显著提高吴茱萸碱的溶出度。
OBJECTIVE: To determine the dissolution of evodiamine dispersible tablets and evodiamine by different methods. Methods: According to the second method (dissolution method) of Dissolution Test of Pharmacopoeia of the People’s Republic of China in 2010, using 900 mL of 1% SDS as dissolution medium and rotating speed of 100 r.min-1 to prepare evodiamine-poloxamer 188 Solid dispersion, evodiamine micropowder and evodiamine micropowder poloxamer 188 solid dispersion, and the dissolution was determined by HPLC. Results: The evodiamine dissolution rate of evodiamine dispersible tablets was> 60% after 45 min. The evodiamine solid solution of evodiamine-poloxamer 188 had good dissolution in vitro. Conclusion: The evodiamine dispersible tablets established method for the determination of dissolution is simple and rapid, can be used as evodiamine dispersible tablets dissolution test; evodiamine almost insoluble in water, ultrafine pulverization combined with solid dispersion technology can significantly improve the evodiamine dissolution degree.