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目的探讨轮状病毒肠炎肌酸激酶同工酶(CK-MB)活性升高的原因以及轮状病毒肠炎是否容易合并心肌损害。方法将80例腹泻病患儿中轮状病毒抗原阳性的38例作为观察组,阴性42例为对照组Ⅰ;另选择18例正常健康体检儿童作为对照组Ⅱ。记录观察组与心肌损害相关的症状和体征,CK-MB活性升高病例的心电图和影像学改变,以及对比3组CK-MB酶活性(免疫抑制法)、酶质量和肌钙蛋白Ⅰ的水平。结果观察组与心肌损害相关症状和体征随腹泻脱水症状的改善而消失,CK-MB活性升高病例的心电图和影像学无心肌损害特异性改变;观察组CK-MB酶活性水平与两对照组相比明显升高(P<0.05),而CK-MB酶质量和肌钙蛋白I的水平3组对比差异无统计学意义(P>0.05)。结论用免疫抑制法测定的CK-MB酶活性在轮状病毒肠炎中升高,但不能据此推断轮状病毒肠炎容易导致心肌损害。
Objective To investigate the reasons for the increased activity of creatine kinase (CK-MB) in rotavirus enteritis and the possibility of rotavirus enteritis complicated with myocardial damage. Methods Thirty eight cases of rotavirus positive in children with diarrhea were selected as observation group and 42 cases as negative control group. Another 18 healthy children were selected as control group Ⅱ. The symptoms and signs related to myocardial damage and the changes of electrocardiogram and imaging of the cases with elevated CK-MB activity were observed in the observation group. The levels of CK-MBase activity (immunosuppression), enzyme quality and troponin I . Results The symptoms and signs related to myocardial damage disappeared with the improvement of diarrhea and dehydration symptoms in the observation group. The electrocardiogram and imaging showed no specific changes of myocardial damage in the patients with elevated CK-MB. The CK-MBase activity in the observation group was significantly lower than that in the two control groups (P <0.05). However, there was no significant difference between the CK-MB enzyme level and the level of troponin I (P> 0.05). Conclusions CK-MBase activity measured by immunosuppression is increased in rotavirus enteritis, but it can not be inferred that rotavirus enteritis easily leads to myocardial damage.