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目的评价以疫苗接种为主的综合干预措施对肾综合征出血热(HFRS)的干预效果。方法对沈阳市2004年发病率在6/10万以上的8个区、县(市)实施综合干预,2012年评价干预效果。结果实施干预措施后,16~60岁适宜人群HFRS疫苗全程接种率达90%以上,疫区(点)灭鼠率达80%以上,临床医生培训覆盖率100%,人群HFRS知识知晓率达90%以上,疫情报告率和报告及时率、疫情规范化处置率和及时率均达100%。干预期2005—2012年,8个干预地区HFRS发病率持续下降,由干预前(2002—2004年)的12.84/10万降至干预后(2012年)的1.03/10万,流行病学控制效果显著,效果指数达12.47,保护率达92.0%。结论以疫苗免疫为主的综合干预措施对控制肾综合征出血热的流行病学效果显著。
Objective To evaluate the intervention effect of comprehensive vaccination-based intervention on hemorrhagic fever with renal syndrome (HFRS). Methods The comprehensive intervention was carried out in 8 districts and counties (cities) with the incidence rate of 6 / 100,000 in Shenyang in 2004, and the effect of intervention in 2012 was evaluated. Results After the interventions were carried out, the whole population vaccination rate of HFRS vaccine was over 90% in the suitable population of 16-60 years old, the rodent elimination rate of epidemic area (point) was over 80%, the training coverage rate of clinicians was 100%, and the awareness rate of HFRS knowledge in the crowd reached 90 %, The reporting rate of epidemic situation and reporting rate of timely, standardized outbreak rate and timely rate reached 100%. Interventions During 2005-2012, the incidence of HFRS in eight intervention areas continued to decline from 12.84 / 100,000 in pre-intervention (2002-2004) to 1.03 / 100,000 in post-intervention (2012). The epidemiological control effect Significantly, the effect index reached 12.47 with a protection rate of 92.0%. Conclusion The epidemiological effect of controlling the hemorrhagic fever with renal syndrome is obvious with the combination of vaccine-based interventions.