新生血管对于肿瘤生长和创伤愈合过程是必不可少的,而血管内皮细胞的增殖和迁移又在新生血管形成的过程中起到关键作用。Periostin是一种细胞黏附蛋白,在多种恶性肿瘤和创伤组织中过表达。在血管形成过程中,它能够通过调控血管内皮细胞的趋化性和趋触性来促进细胞的迁移,而这一过程是通过活化FAK-PI3K-AKT信号途径实现的;在低氧环境中,periostin能够促进内皮细胞的增殖并抑制其凋亡。 Neovascularization is essential for tumor growth and wound healing, and vascular endothelial cell proliferation and migration in turn play a key role in neovascularization. Periostin is a cell adhesion protein that is overexpressed in a variety of malignancies and wound tissues. In the process of angiogenesis, it can promote the migration of cells by regulating the chemotaxis and tropism of vascular endothelial cells, which is through the activation of FAK-PI3K-AKT signaling pathway. In hypoxic environment, Periostin can promote endothelial cell proliferation and inhibit its apoptosis.