本文报告55例四肢骨肉瘤,在手术切除肿瘤(截肢或瘤段切除)后加用多种药物化疗的结果,并随访30～80个月。一、资料和方法。 55例中男43、女12。年龄7～82岁(平均18岁)。肿瘤发生的部位:股骨29、胫骨18、肱骨4、腓骨2,骨盆及桡骨各1。手术方法:截肢术或关节解脱术47、局部瘤段切除8(肿瘤局限于骨内,常在上肢采用)。40例在手术时做活检,15例先作活检,1～2周后手术。化疗药物应用方法(附表)。早期即用化疗,其理由如下:1.可以阻止手术时产生的瘤栓播散,采用肝素亦是这个道理,因为血栓形成后对瘤细胞有保护作用,使化疗药物及机体的防卫机制不能对它发生作 This article reports the results of 55 cases of osteosarcoma of the extremities after surgical removal of the tumor (ampullectomy or resection of the tumor) plus multiple drug chemotherapy and follow-up for 30 to 80 months. First, information and methods. In 55 cases, there were 43 males and 12 females. Age 7-82 years old (mean 18 years old). The site of the tumor: femur 29, sacrum 18, sacrum 4, sacrum 2, pelvis and sacrum 1. Surgical methods: amputation or joint relief surgery 47, local tumor resection 8 (tumor confined to the bone, often used in the upper extremity). Forty patients underwent biopsy at the time of surgery. Fifteen patients first had a biopsy and one to two weeks later. Chemotherapy drug application method (attached table). Early use of chemotherapy, the reasons are as follows: 1. Can prevent tumor thrombosis disseminated during surgery, the use of heparin is also the reason, because the thrombosis after the protection of tumor cells, so that the chemotherapeutic drugs and the body’s defense mechanism can not It happened