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nm23-H1基因编码一类似于核苷二磷酸激酶的蛋白而且可能通过微管集合和分散以及经G蛋白的信号转导参与维持正常组织构建和细胞与细胞的关系。因此,已提示它的异常表达可能有助于新生瘤细胞的扩散。本研究旨在确定孤立肝细胞癌(HCC)<5cm而经手术切除患者的肝内肿瘤复发与nm23-H1 mRNA表达间的关系。 研究两组患者,A组为患孤立HCC、<5cm、接受手术切除而在随访中发生肝内疾病早期复发的肝硬化患者7例。他们至复发检出的中位时间为12(3～24)个月。所有这些患者的HCC复发由常规US随访检出并经细针抽吸活检和/或AFP水平升高证实。B组为患孤立HCC、<5cm、接受手术切除而存
The nm23-H1 gene encodes a protein similar to nucleoside diphosphokinase and may participate in the maintenance of normal tissue construction and cell-cell relationship through microtubule assembly and dispersion and signal transduction via the G protein. Therefore, it has been suggested that its abnormal expression may contribute to the proliferation of neoplastic cells. The aim of this study was to determine the relationship between intrahepatic tumor recurrence and nm23-H1 mRNA expression in patients with isolated hepatocellular carcinoma (HCC) < 5 cm. Two groups of patients were studied. Group A was 7 patients with cirrhosis who had isolated HCC, <5 cm, and who underwent surgical resection and early recurrence of intrahepatic disease during follow-up. Their median time to recurrence was 12 (3 to 24) months. HCC recurrence in all these patients was confirmed by routine US follow-up and confirmed by fine needle aspiration biopsy and/or elevated AFP levels. Group B is suffering from isolated HCC, <5cm, and surgical resection