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大肠癌的发病率与死亡率逐年上升,严重威胁人们的身心健康,平均5年生存率低于40％。积极探讨大肠癌综合治疗的新手段有重要的临床和社会经济意义。研究表明,多种肿瘤的发生与细胞凋亡障碍有关,诱导肿瘤细胞凋亡可能成为肿瘤治疗中有前景的手段之一。三氧化二砷(As_2O_3)是近年来新认识的对多种肿瘤有良好效果的药物,能诱导多种肿瘤细胞凋亡,但对大肠癌的作用未见报道,我们对此进行初步探讨。
The incidence and death rate of colorectal cancer has increased year by year, which seriously threatens people’s physical and mental health. The average 5-year survival rate is less than 40%. Actively exploring new approaches for comprehensive treatment of colorectal cancer has important clinical and socioeconomic implications. Studies have shown that the occurrence of a variety of tumors is associated with apoptosis disorders, and induction of tumor cell apoptosis may become one of the promising approaches in the treatment of cancer. The arsenic trioxide (As2O3) is a newly recognized drug with good effects on many kinds of tumors in recent years. It can induce apoptosis of many kinds of tumor cells, but its effect on colorectal cancer has not been reported. We have conducted preliminary discussions on this.