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消炎痛[化学名为1-(对氯苯甲酰)-5-甲氧基-2-甲基吲哚-3-醋酸]是一种应用广泛的非甾体类抗炎药,特别是对骨关节炎有一定疗效,口服后很快自胃肠道吸收,大约90％与血浆蛋白结合,50％在肝脏微粒体混合功能氧化酶(MFO)系统作用下发生邻位去甲基化,部分在肝脏的非微粒体酶系统作用下发生N-脱酰化,20％以原形自尿中排除。消炎痛与其它药物联合应用,由于相互作用就有可能产生副作用。因为此药物主要由
Indomethacin [chemical name 1- (p-chlorobenzoyl) -5-methoxy-2-methylindole-3-acetic acid] is a widely used nonsteroidal anti-inflammatory drug, Osteoarthritis has a therapeutic effect, absorbed rapidly from the gastrointestinal tract after oral administration, about 90% of the plasma protein binding, 50% in the liver microsomal mixed function oxidase (MFO) system under ortho-demethylation, part N-deacylation occurs under the action of the liver’s non-microsomal enzyme system, with 20% of the prototype being excluded from the urine. Indomethacin is used in combination with other drugs and may have side effects due to interactions. Because this medicine is mainly by