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本文就心得安与下列药物的不良相互作用介绍如下。 1.肾上腺素:接受心得安者再加用肾上腺素时可显著升高血压和发生心动过缓。其机制为肾上腺素同时刺激心血管系统的α和β受体。α刺激引起血管收缩,而β刺激引起血管扩张和心率增加,当β受体阻滞时,α受体的血管收缩作用呈现显著血压升高,进而由于迷走神经张力增加而出现心动过缓。 2.异丙肾上腺素:众所周知,异丙肾上腺素常作为支气管扩张剂使用,而心得安禁用于哮喘者。两药并用在支气管β受体上有相互拮抗作用。
In this article, propranolol and the following adverse drug interactions are described below. 1. Adrenaline: Receiving an extra dose of epinephrine can significantly increase blood pressure and bradycardia. The mechanism is that epinephrine simultaneously stimulates the cardiovascular system’s alpha and beta receptors. α stimulates vasoconstriction, whereas β stimulates vasodilation and increases heart rate. When β blockade occurs, vasoconstriction of α receptors exhibits marked elevation of blood pressure, which in turn leads to bradycardia due to increased vagal tone. Isoproterenol: It is well-known that isoproterenol is often used as a bronchodilator, and is forbidden for asthma. Two drugs used in the bronchial β receptor antagonistic effect.