目的用半数致死量来评价三聚氰胺的急性毒性。方法分别选用的清洁级健康成年雌雄两种性别的昆明小鼠各20只,在清洁级动物室隔夜禁食16h后,按霍恩氏法采用21500、10000、4640、2150mg/kg.bw的剂量经口给予三聚氰胺后,观察在14天内动物所产生的毒性反应。结果经口给予小鼠三聚氰胺,其LD50为5840mg/kg.bw。结论根据LD50数值,依据WHO外源化学物急性毒性分级标准,判定三聚氰胺毒性分级为微毒物质。 Objective To assess the acute toxicity of melamine using median lethal dose. METHODS: Twenty healthy male and female Kunming mice, each of which was healthy and male and female, were selected. After fasting for 16 hours overnight in clean animal houses, the Horn’s method was used at doses of 21500, 10000, 4640 and 2150 mg / kg.bw After oral administration of melamine, the toxicity of the animals within 14 days was observed. Results Mice were orally administered with LD50 of 5840 mg / kg.bw. Conclusion According to the LD50 value, according to the WHO acute toxicity classification criteria of foreign chemicals, the melamine toxicity grade was judged to be a micro-toxic substance.