血管新生是指原有的毛细血管或后毛细血管静脉新生血管的过程。1971年 Forlkman首次证实 [1 ] :实体瘤在缺乏血管新生的条件下仅能生长至 2～ 3cm。随后的研究又发现 :肿瘤的生长有赖于血管新生。肿瘤组织中的新生血管不仅为瘤体提供氧份及营养物质 ,而且为肿瘤转移及血管浸润 Angiogenesis refers to the process of angiogenesis in the original capillary or posterior capillaries. In 1971, Forlkman first confirmed [1] that solid tumors can only grow to 2 to 3 cm in the absence of angiogenesis. Subsequent studies also found that the growth of tumors depends on angiogenesis. Neovascularization in tumor tissue not only supplies oxygen and nutrients to tumors, but also metastases and vascular invasion