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固有免疫是宿主防御病原微生物入侵的第一道防线。宿主通过胚系基因编码的模式识别受体(pathogen recognition receptor,PRR)监测微生物的病原相关分子模式(病毒核酸等),迅速启动免疫应答反应。宿主自身的核酸如果错误地出现在细胞质中,也会被模式识别受体识别,引发自身免疫疾病。STING(stimulator of interferon genes)是最近鉴定出的内质网接头蛋白,可以动态监控细胞内DNA以及环二核苷酸(cyclic dinucleotides,CDNs)的异常存在,发挥承上启下的抗微生物感染的枢纽功能。该文概述STING介导的细胞信号通路前沿进展,并对有待突破的科学问题作出展望。
Inherent immunity is the host’s first line of defense against pathogenic microorganisms. Hosts monitor the pathogen-associated molecular patterns of microorganisms (viral nucleic acids, etc.) through the pathogen recognition receptor (PRR) encoded by germline genes and rapidly initiate an immune response. If the host’s own nucleic acid mistakenly appears in the cytoplasm, it will also be recognized by the pattern recognition receptors, triggering an autoimmune disease. STING (stimulator of interferon genes) is a recently identified endoplasmic reticulum adapter protein that dynamically monitors intracellular DNA and the abnormal presence of cyclic dinucleotides (CDNs), playing a pivotal role in the development of antimicrobial infections. This article summarizes STING-mediated advances in cell signaling pathways and looks forward to the scientific issues to be overcome.