内质网是具有重要生理功能的细胞器,是细胞内Ca2+贮存器,负责蛋白的生物合成、折叠、组装和修饰。内质网对各种刺激非常敏感,蛋白折叠需求增强或外界刺激等因素,均可引起内质网蛋白折叠负荷与蛋白折叠能力之间的不平衡,造成未折叠蛋白或错误折叠蛋白在内质网腔内蓄积,即诱发内质网应激(endoplasmic reticulum stress,ERS)。为了确保蛋白折叠的精准性,防止未折叠蛋白或错误折叠蛋白在内质网腔内蓄积, Endoplasmic reticulum is an organelle with important physiological functions. It is an intracellular Ca2 + reservoir responsible for protein biosynthesis, folding, assembly and modification. Endoplasmic reticulum is very sensitive to various stimuli, protein folding demand or external stimuli and other factors, can cause endoplasmic reticulum protein folding load and protein folding capacity imbalance, resulting in unfolded protein or misfolded protein in the endoplasmic reticulum Accumulation of intraluminal, that is induced by endoplasmic reticulum stress (endoplasmic reticulum stress, ERS). In order to ensure the accuracy of protein folding and to prevent the accumulation of unfolded proteins or misfolded proteins in the endoplasmic reticulum lumen,