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双吡啶醛肟季铵盐类对某些有机磷酸酯类中毒具有明显的对抗作用,因此合成了一类4-偕胺肟双吡啶季铵碘盐化合物(1a～1n),以期找出更有效的抗毒剂. CONR_2取代在3位:NR_2=NH_2(a),N(CH_3)_2(b),N(C_2H_5)2(c),NHC_3H_(7-n)(d),NHC_3H_(7-i)(e),NHC_4H_9n(f),NHC_4H_(9-i)(g), CONR_2取代在4位:NR_2=NH_2(1),NHC_3H_(7-n)(m),这类新化合物的合成是以4-吡啶甲酸(2)制得4-氰基吡啶(3),再与盐酸羟胺作用制得4-吡啶偕胺肟(4),然后与α,α’-二氯甲醚作用制得N-氯甲氧甲基-4-吡啶偕胺肟氯盐(简称单氯盐,5),最后与相应的N-取代吡啶甲酰胺(6)作用而得.
Pyridinium aldoxime quaternary ammonium salts have obvious antagonistic effect on some organophosphate poisoning. Therefore, a class of 4-amidoxime bipyridine quaternary ammonium iodonium compounds (1a ~ 1n) were synthesized in order to find out more effective Of the anticonvulsant CONR_2 was replaced by CONR_2 at position 3: NR_2 = NH_2 (a), N (CH_3) _2 (b), N (C_2H_5) 2 (c), NHC_3H_ (7-n) The new compounds were synthesized by substituting CONR_2 for position 4: NR_2 = NH_2 (1), NHC_3H_ (7-n) (m), NHC_4H_9n (f) and NHC_4H_9n (g) 4-Pyridinecarboxylic acid (2) 4-cyanopyridine (3), and then hydroxylamine hydrochloride role 4-pyridine amidoxime (4), and then with α, α’- dichloro methyl ether role N-Chloromethoxymethyl-4-pyridine amidoxime chloride (abbreviated as monochloride salt, 5), finally with the corresponding N-substituted pyridine carboxamide (6) role derived.