论文部分内容阅读
17例未曾治疗的瘤型麻风患者用延效氨苯砜(DADDS)治疗,每11周肌内注射225毫克。治疗前及治疗后4、12和24周分别自皮肤取材接种小鼠足垫。所有患者治疗前的皮肤中均有能在小鼠足垫中繁殖的麻风菌。根据治疗后麻风菌被杀死的速度,即麻风菌失去对小鼠足垫感染能力的速度,判断DADDS的疗效。17例患者根据DADDS的疗效可分4组:第一组4例,治疗后各次活检标本中的麻风菌在小鼠中都不能繁殖;第二组4例,治疗4周后麻风菌能繁殖,但12及24周后则不能;第三组7例,治疗4及12周后麻风菌能繁殖,但24周后不能;第四组2例,直到治疗后24周麻风菌仍能繁殖。当皮肤标本中的麻风菌在小鼠中繁殖后每株传代接种60只小鼠,每只小鼠的后足垫分别接种5×10~3条菌,均分4组,1组不治疗,其余3组分别自
Seventeen untreated nodules were treated with dapsone (DDPDS) and 225 mg intramuscularly every 11 weeks. Before treatment and 4, 12 and 24 weeks after treatment, the mice were respectively inoculated with mouse foot pads from the skin. All patients had leprosy capable of reproducing in the mouse footpad in the skin before treatment. According to the rate of leprosy being killed after treatment, that is, the rate of leprosy losing the ability to infect footpads in mice, the efficacy of DADDS was judged. Seventeen patients were divided into 4 groups according to the therapeutic effect of DADDS: 4 cases in the first group, and no leprosy in each biopsy sample after treatment; 4 mice in the second group, 4 weeks after treatment, , But not after 12 and 24 weeks. In the third group, 7 leprosy could be reproduced after 4 and 12 weeks of treatment, but not after 24 weeks. In the fourth group, 2 cases remained alive until 24 weeks after treatment. When the leprosy in the skin specimen was propagated in the mice, 60 mice were inoculated per passage, and the rear foot pads of each mouse were inoculated with 5 × 10 ~ 3 bacteria respectively, divided into 4 groups, one group was not treated, The remaining three groups from