BRCA1基因编码一个220kDa的多功能区核蛋白,能与癌基因蛋白(c-myc、E2F等)、抑癌基因蛋白(p53、RB、BRCA2)、DNA修复相关蛋白(RAD50、RAD51)、细胞周期调节蛋白(cyclinsandCDKs)以及转录调节因子(RNApolymeraseⅡ)等多种重要蛋白相互作用,不仅能抑制细胞生长,还参与细胞周期调控、基因转录调节、DNA损伤修复以及凋亡等多种细胞活动,在维持基因组稳定性中起重要作用。本文对BRCA1的生化结构及其在维持基因组稳定性中的作用做一综述。 The BRCA1 gene encodes a 220 kDa multifunctional region of the nucleoprotein that interacts with oncogene proteins (c-myc, E2F, etc.), tumor suppressor proteins (p53, RB, BRCA2), DNA repair related proteins (RAD50, RAD51) Cyclinsand CDKs and many other important proteins such as RNApolymeraseⅡcan not only inhibit the cell growth but also participate in many cell activities such as cell cycle regulation, gene transcription regulation, DNA damage repair and apoptosis, Genome stability plays an important role. This review summarizes the biochemical structure of BRCA1 and its role in maintaining genome stability.