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目的探讨水化疗法中不同饮水量对强化计算机断层扫描(computed tomography,CT)后造影剂排泄的影响,寻求适宜的水化剂量,加速造影剂在体内的排泄,降低造影剂对人体产生风险,保证患者临床安全.方法选择符合条件的200例患者,按随机数字表分为4组,每组50例,实施规范化的口服水化护理方案:强化CT后3 h定时、定量饮水,即在3 h内分别饮水1000、1500、2000、2500 m L,然后留取:强化C T前、强化CT后2、4、6、8、10、12、14 h共8个时间点的尿标本,用CT进行扫描,通过对比CT值,观察造影剂排泄情况.结果4组胰腺癌的患者水化疗法后对造影剂的排泄率有显著差异(χ~2=29.14,P<0.01),第2组与第3组比较(χ~2=8.58,P<0.01),差异具有统计学意义,第1组与第2组比较(χ~2=1.6,P>0.01),第3组与第4组比较(χ~2=0.21,P>0.01)均没有统计学意义.从胃部舒适度来看,仅第3组与第4组(χ~2=5.01,P<0.05)具有统计学意义,水化剂量2000 m L比2500 m L组引起胃部不适率较低.故3 h内的水化剂量2000 mL使造影剂的排泄率显著优于其他组,而胃部舒适度较好.结论在强化CT后3 h内口服水化剂量2000 m L可以加速造影剂在体内的排泄,从而减低造影剂对人体产生的风险,保障患者安全.
Objective To investigate the influence of different drinking water in hydration therapy on the excretion of contrast agent after computed tomography (CT), to find the appropriate amount of hydration, to accelerate the excretion of contrast agent in vivo, and to reduce the risk of contrast agent to human body. To ensure clinical safety of patients. Methods Choose 200 patients who meet the conditions, according to a random number table is divided into 4 groups, 50 cases in each group, the implementation of standardized oral hydration care program: 3h after strengthening CT timing and quantitative drinking water, that is, in 3 Within the h, drink 1000, 1500, 2000, and 2500 m L, and then take urine specimens before and after strengthening CT: 2, 4, 6, 8, 10, 12 and 14 h after CT Scans were performed to compare the CT values and observe the excretion of contrast agents. Results There was a significant difference in the excretion rate of contrast agents after hydration therapy in 4 groups of pancreatic cancer patients (χ~2=29.14, P<0.01). The third group was compared (χ~2=8.58, P<0.01), and the difference was statistically significant. The first group was compared with the second group (χ~2=1.6, P>0.01). The third group was compared with the fourth group. (χ~2=0.21, P>0.01) were not statistically significant. From the viewpoint of gastric comfort, only the third group and the fourth group (χ~2=5.01, P<0.05) were statistically significant. Chemical dosage The 2000 m L was lower than the 2500 m L group, causing a lower stomach discomfort rate. Therefore, the 2000 mL hydration dose within 3 h was superior to the other groups in the excretion rate of the contrast agent, and the stomach comfort was better. Conclusion In the enhanced CT The oral hydration dose of 2000 m L within 3 h after the injection can accelerate the excretion of the contrast agent in the body, thereby reducing the risk of the contrast agent to the human body and ensuring the safety of the patient.