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用免疫组化方法检测27例子宫颈癌基底膜的变化,发现在正常、不典型增生和原位癌,其上皮细胞与间质之间有明显而连续的基底膜。在常规染色疑有早期浸润癌的病变,显示出不连续的基底膜。根据癌细胞的分化程度,浸润癌基底膜表现为不连续、碎片状或完全消失。结果表明基底膜与肿瘤分化有关,基底膜的免疫组化检测有助于区别子宫颈原位癌和早期浸润癌,并可能有助于鳞癌的分级。
Immunohistochemical method was used to detect the changes of 27 cases of cervical cancer basement membrane, found in normal, dysplasia and carcinoma in situ, the epithelial cells and interstitial obvious and continuous basement membrane. In conventional staining suspected of early invasive carcinoma of the lesion, showing a discontinuous basement membrane. According to the degree of differentiation of cancer cells, infiltrating basal lamina showed discontinuous, fragmented or completely disappeared. The results show that the basement membrane and tumor differentiation related to the basement membrane immunohistochemical detection can help distinguish between cervical carcinoma in situ and early invasive cancer, and may contribute to the classification of squamous cell carcinoma.