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Forty-eight children with sepsis were studied. Interleukin-13 (IL-13) levels were lower in patients who died at admission (P = 0.014) and at 6 h (P = 0.037), and in patients with refractory shock at 0 (P = 0.03) and particularly at 6 h (P = 0.0009). IL-13 levels did not correlate with other cytokines (IL-1b, IL-10, IL-12, TNFr), CRP or neutrophil count. Low IL-13 levels in the early hours of sepsis are associated with poor prognosis. Conclusion: IL-13, a Th-2 cytokine fundamental in the pathogenesis of atopy,might also have a protective role against severe infections in children.
Interleukin-13 (IL-13) levels were lower in patients who died at admission (P = 0.014) and at 6 h (P = 0.037), and in patients with refractory shock at 0 IL-13 levels did not correlate with other cytokines (IL-1b, IL-10, IL-12, TNFr), CRP or neutrophil count. levels in the early hours of sepsis are associated with poor prognosis. Conclusion: IL-13, a Th-2 cytokine fundamental in the pathogenesis of atopy, might also have protective role against severe infections in children.