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目的探讨肺癌中E钙粘蛋白的表达和微血管密度的关系及意义。方法用SP免疫组化技术检测E钙粘蛋白和Ⅷ因子在104例肺癌组织中的表达,利用图象分析系统计算微血管密度。结果E钙粘蛋白与肺癌分级有密切关系,随分化程度的降低,E钙粘蛋白的阳性率明显下降(P<0.05),且呈现异常表达。E钙粘蛋白表达还与肺癌组织微血管密度呈显著负相关(P=0.047)。结论E钙粘蛋白表达的降低和微血管密度的增加可能在促进肺癌浸润转移中起重要作用。
Objective To investigate the relationship between E-cadherin expression and microvessel density in lung cancer and its significance. Methods SP immunohistochemistry was used to detect the expression of E-cadherin and factor Ⅷ in 104 lung cancer tissues. The microvessel density was calculated by image analysis system. Results E-cadherin was closely related to the grade of lung cancer. With the decrease of differentiation, the positive rate of E-cadherin decreased significantly (P <0.05), and showed abnormal expression. E-cadherin expression was also significantly negatively correlated with microvessel density in lung cancer (P = 0.047). Conclusion The decrease of E-cadherin expression and the increase of microvessel density may play an important role in promoting the invasion and metastasis of lung cancer.