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目的探讨艾滋病患者经高效抗逆转录病毒疗法(HAART)治疗后所取得的临床效果。方法采用流行病学描述性研究的方法,从5个纬度对湖北省随州市181例艾滋病患者治疗后临床症状、79例病毒载量和免疫功能的改变情况进行描述,用Epi Data双人录入数据,SPSS 13.0软件建立数据库,并进行统计学分析。结果对不规则发热、咳嗽、腹泻、淋巴结肿大、体质量下降、皮疹、真菌感染有效率分别为81.39%、85.00%、84.62%、81.89%、82.86%、66.07%和45.45%。用药后CD4~+T淋巴细胞计数明显升高,3个月CD4~+T淋巴细胞计数平均为276×10~6/ml(65×10~6/ml～824×10~6/ml),上升129×10~6/ml。6个月CD4~+T淋巴细胞计数平均为294×10~6/ml(102×10~6/ml～750×10~6/ml)。用药后6个月与3个月相比较无明显变化。停药者中死亡人数14例,病死率29.79%;未停药者死亡人数3例,病死率2.24%。结论HAART治疗可明显改善艾滋病患者的临床症状,有效降低病毒载量,提高临床依从性可降低病死率。
Objective To explore the clinical effect of AIDS patients treated with highly active antiretroviral therapy (HAART). Methods According to epidemiological descriptive study, clinical symptoms, 79 viral load and immune function changes of 181 AIDS patients in Suizhou, Hubei province were described from 5 latitudes. Data were entered into Epi Data double, SPSS 13.0 software to establish a database, and for statistical analysis. Results The rates of irregular fever, cough, diarrhea, swollen lymph nodes, weight loss, skin rashes and fungal infections were 81.39%, 85.00%, 84.62%, 81.89%, 82.86%, 66.07% and 45.45%, respectively. The counts of CD4 ~ + T lymphocytes were significantly increased after treatment. The counts of CD4 ~ + T lymphocytes at 3 months were 276 × 10 ~ 6 / ml (65 × 10 ~ 6 / ml ~ 824 × 10 ~ 6 / ml) Rose 129 × 10 ~ 6 / ml. The average count of CD4 ~ + T lymphocytes in 6 months was 294 × 10 ~ 6 / ml (102 × 10 ~ 6 / ml ~ 750 × 10 ~ 6 / ml). Six months after treatment compared with 3 months no significant change. The number of deaths in drug users in 14 cases, the mortality rate of 29.79%; non-stop drug in the number of deaths in 3 cases, the fatality rate of 2.24%. Conclusion HAART treatment can significantly improve the clinical symptoms of AIDS patients, effectively reduce the viral load and improve clinical compliance can reduce mortality.