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对米非司酮配伍卡前列甲酯栓(PG05)或米索前列醇(米索)用于120例孕10～16周妊娠妇女(随机分为四组)进行了终止妊娠效果的观察。对象一次或分次服米非司酮200mg后48小时,分别使用米索(Ⅰ、Ⅱ组)或PG05(Ⅲ、Ⅳ组),有效率分别为80.0％、80.0％、96.7％、100％。伍用PG05效果明显优于伍用米索。引流产时间分别为5.79、6.54、5.53、6.49小时,四组间无差异。Ⅲ、Ⅳ组副反应高于Ⅰ、Ⅱ组。结论:米非司酮200mg配伍PG05或米索是终止孕10～16周妊娠安全有效的方法。观察中PG05的效果高于米索,考虑可能与米索的剂量偏低有关。由于存在不全流产率较高及潜在的子宫破裂、宫颈裂伤危险,终止妊娠需加强监护。
Mifepristone compatibility with carbamazepin suppository (PG05) or misoprostol (misoprostol) for 120 pregnant women 10 to 16 weeks pregnant women (randomly divided into four groups) were observed the effect of termination of pregnancy. Subjects were treated with misoprostol (Group Ⅰ, Ⅱ) or PG05 (Group Ⅲ, Ⅳ) 48 hours after taking mifepristone 200 mg once or twice daily. The effective rates were 80.0%, 80.0%, 96.7% and 100%, respectively. Wu PG05 effect was significantly better than the team with misoprostol. Drainage time were 5.79,6.54,5.53,6.49 hours, no difference between the four groups. The side reactions in group Ⅲ and Ⅳ were higher than those in group Ⅰ and Ⅱ. Conclusion: 200mg mifepristone with PG05 or misoprostol is a safe and effective method to terminate the pregnancy of 10 ~ 16 weeks. The effect of PG05 in observation is higher than that of misoprostol, which may be related to the low dose of misoprostol. Due to the high prevalence of incomplete abortion and potential uterine rupture, the risk of cervical laceration, termination of pregnancy need to be intensive care.