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过去二十年间非酒精性脂肪性肝病（NAFLD）患病率快速增长，已成为最常见的慢性肝脏疾病，给患者及其家庭带来沉重负担。有必要全面评估NAFLD患者的生活质量，帮助制定和实施更有效的干预治疗策略。目前，常用于评估NAFLD患者生活质量的量表有通用量表医学结果研究简表36、疾病特异性量表慢性肝病问卷等。国内外研究结果显示NAFLD患者生活质量明显低于健康人群，此类患者的生活质量随疾病加重而进行性降低，且可能低于其他慢性肝病患者；究其原因，可能与患者体质量指数、合并症等因素相关。临床实践中，生活质量评估可全面体现NAFLD患者健康水平，有助于确立个体化治疗目标，同时综合评价疾病和临床干预对患者的影响。“,”Over the past two decades, the incidence of non-alcoholic fatty liver disease (NAFLD) has risen sharply and has become the most common chronic liver disease, placing a heavy burden on patients and their families. A comprehensive assessment of the quality of life (QoL) of NAFLD patients is necessary to develop and implement more effective intervention strategies. Currently, the disease-specific scales commonly used to assess the quality of life of NAFLD patients include the 36-Item Short-Form Health Survey questionnaire (SF-36), Chronic Liver Disease Questionnaire (CLDQ), and so on. The research results of home and abroad showed that the quality of life of NAFLD patients is significantly lower than that of healthy people, and with the aggravation of the disease, the quality of life of such patients decreases, and may even be lower than other patients with chronic liver disease, and the reason for this may be related to factors such as body mass index (BMI) and complications. In clinical practice, the assessment of quality of life can fully reflect the health status of NAFLD patients, thereby helping to establish the personalized treatment goals to comprehensively assess the impact of disease on patients with clinical interventions.