苯妥英钠(DPH)是临床上最常用的抗癫痫药物之一。长期服用治疗量的DPH,能引起小脑萎缩,国内尚少报道。本文报道5例经CT证实的小脑萎缩,结合文献分析讨论如下。 一、临床资料 本组5例病人,男3例,女2例。年龄6～42岁,呈发作性短暂意识丧失伴肢体抽搐,EEG典型病样放电,诊断为癫痫大发作。服DPH时间5～38年, Phenytoin sodium (DPH) is one of the most commonly used antiepileptic drugs in the clinic. Long-term treatment of the amount of DPH, can cause cerebellar atrophy, less reported in China. This article reports 5 cases of cerebellar atrophy confirmed by CT, combined with literature analysis discussed below. First, clinical data The group of 5 patients, 3 males and 2 females. Age 6 to 42 years old, was episodic short-term loss of consciousness associated with limbs convulsions, EEG typical disease-like discharge, the diagnosis of epileptic seizures. DPH time 5 to 38 years,